Formulasi Sediaan Pembalut Luka Hidrogel Berbasis Pektin Kulit Loka Pere (Musa spp.)
DOI:
https://doi.org/10.63004/hrji.v4i6.1427Kata Kunci:
Hidrogel, Loka Pere, Pektin, Pembalut lukaAbstrak
Ulkus diabetik merupakan komplikasi serius diabetes melitus yang ditandai penyembuhan luka lambat dan risiko infeksi tinggi. Pembalut luka berbasis hidrogel dari bahan alam lokal menjadi pendekatan menjanjikan untuk mendukung penyembuhan luka kronik. Penelitian ini bertujuan mengembangkan dan mengevaluasi sediaan pembalut luka hidrogel berbasis pektin yang diekstraksi dari kulit Loka Pere (Musa spp.) serta menilai sifat fisik dan stabilitasnya sebagai kandidat pembalut luka ulkus diabetik. Pektin diekstraksi dari 1.000 g tepung kulit Loka Pere dengan metode ekstraksi asam dan diformulasikan menjadi hidrogel pada variasi konsentrasi 2,5%; 5%; 7,5%; dan 10% b/b. Evaluasi meliputi uji organoleptis, homogenitas, pH, daya sebar, serta stabilitas fisik selama penyimpanan suhu ruang empat minggu dengan interval tujuh hari. Rendemen pektin sebesar 3% dan seluruh formula berkonsistensi kental semi padat, homogen, beraroma khas bahan. Nilai pH berada pada rentang asam (3,50–3,75) yang berpotensi mendukung penyembuhan luka kronik. Formula F1 memenuhi kriteria daya sebar sediaan semipadat topikal (5–7 cm), sedangkan konsentrasi pektin lebih tinggi menunjukkan daya sebar berlebihan. Selama penyimpanan, hidrogel relatif stabil tanpa perubahan bermakna pada organoleptik dan homogenitas. Berdasarkan hasil tersebut, hidrogel berbasis pektin kulit Loka Pere berpotensi dikembangkan sebagai pembalut luka untuk mendukung penyembuhan ulkus diabetik.
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Hak Cipta (c) 2026 Anisa Dwirizky Abdullah, Auliah Rahmi Latif, Putri Ramdaniah, Aulia Wardani, Fitriani Fitriani, Elsapira Elsapira
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