Perbandingan Natrium Serum Pre dan Post Hemodialisis pada Pasien Gagal Ginjal Kronis di RSUD Kotamobagu
DOI:
https://doi.org/10.63004/hrji.v4i5.1281Kata Kunci:
Gagal Ginjal Kronik, Hemodialisis, kadar natrium serum, Ion Selective Electrode (ISE)Abstrak
Penyakit ginjal kronis (PGK) merupakan gangguan progresif dan irreversibel yang menyebabkan penurunan fungsi ginjal dalam menjaga keseimbangan cairan dan elektrolit, termasuk natrium serum. Ketidakseimbangan natrium pada pasien PGK yang menjalani hemodialisis dapat meningkatkan risiko komplikasi, sehingga pemantauan kadar natrium perlu dilakukan secara rutin. Penelitian ini bertujuan untuk menganalisis perbedaan kadar natrium serum sebelum dan sesudah hemodialisis pada pasien gagal ginjal kronis di RSUD Kotamobagu. Penelitian ini menggunakan desain deskriptif kuantitatif dengan pendekatan cross-sectional. Sampel berjumlah 29 pasien yang dipilih menggunakan teknik total sampling. Pemeriksaan natrium serum dilakukan dengan metode Ion Selective Electrode (ISE) pada autoanalyzer, kemudian data dianalisis menggunakan uji Paired Sample T-Test. Hasil penelitian menunjukkan bahwa sebelum hemodialisis, 89,66% pasien memiliki kadar natrium normal dan 10,34% rendah. Setelah hemodialisis, kadar natrium normal meningkat menjadi 93,10%, sedangkan kadar rendah menurun menjadi 6,90%. Hasil uji statistik menunjukkan nilai p=0,277, sehingga tidak terdapat perbedaan bermakna antara kadar natrium serum sebelum dan sesudah hemodialisis. Dengan demikian, hemodialisis belum menunjukkan perubahan signifikan terhadap kadar natrium serum, meskipun terjadi perbaikan proporsi kadar natrium normal.
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Referensi
Arzhan, S., Lew, S. Q., & Ing, T. S. (2021). Dysnatremias in chronic kidney disease: Pathophysiology, manifestations, and treatment. Frontiers in Medicine, 8, 769287. https://doi.org/10.3389/fmed.2021.769287
Fujisaki, K., Joki, N., Tanaka, S., Kanda, E., Hamano, T., Masakane, I., & Tsuruya, K. (2021). Pre-dialysis hyponatremia and change in serum sodium concentration during a dialysis session are significant predictors of mortality in patients undergoing hemodialysis. Kidney International Reports, 6(2), 342–350. https://doi.org/10.1016/j.ekir.2020.11.009
Hecking, M., Karaboyas, A., Saran, R., Sen, A., Hörl, W. H., Pisoni, R. L., Robinson, B. M., Sunder-Plassmann, G., & Port, F. K. (2012). Predialysis serum sodium level, dialysate sodium, and mortality in maintenance hemodialysis patients: The Dialysis Outcomes and Practice Patterns Study (DOPPS). American Journal of Kidney Diseases, 59(2), 238–248. https://doi.org/10.1053/j.ajkd.2011.07.013
Hill, N. R., Fatoba, S. T., Oke, J. L., Hirst, J. A., O’Callaghan, C. A., Lasserson, D. S., & Hobbs, F. D. R. (2016). Global prevalence of chronic kidney disease—A systematic review and meta-analysis. PLoS ONE, 11(7), e0158765. https://doi.org/10.1371/journal.pone.0158765
Hockham, C., Bao, L., Tiku, A., Badve, S. V., Bello, A. K., Jardine, M. J., Jha, V., Toyama, T., Woodward, M., & Jun, M. (2022). Sex differences in chronic kidney disease prevalence in Asia: A systematic review and meta-analysis. Clinical Kidney Journal, 15(6), 1144–1151. https://doi.org/10.1093/ckj/sfac030
Kementerian Kesehatan Republik Indonesia. (2018). Hasil utama Riskesdas 2018. Badan Penelitian dan Pengembangan Kesehatan.
Kim, H. Y. (2019). Statistical notes for clinical researchers: The independent samples t-test. Restorative Dentistry & Endodontics, 44(3), e26. https://doi.org/10.5395/rde.2019.44.e26
Kovesdy, C. P. (2022). Epidemiology of chronic kidney disease: An update 2022. Kidney International Supplements, 12(1), 7–11. https://doi.org/10.1016/j.kisu.2021.11.003
Li, J., Song, P., Yang, D., & Liu, Y. (2022). A systematic review and meta-analysis: Hyponatremia predicted all-cause and cardiovascular mortality in dialysis population. Blood Purification, 51(4), 345–354. https://doi.org/10.1159/000517340
Liang, G., Fu, W., & Wang, K. (2019). Analysis of t-test misuses and SPSS operations in medical research papers. Burns & Trauma, 7, 31. https://doi.org/10.1186/s41038-019-0170-3
Liu, Q., Zheng, K., Wang, H., Song, D., & Li, X. (2024). Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event. Renal Failure, 46(1), 2338483. https://doi.org/10.1080/0886022X.2024.2338483
Luyckx, V. A., Tonelli, M., & Stanifer, J. W. (2018). The global burden of kidney disease and the sustainable development goals. Bulletin of the World Health Organization, 96(6), 414–422D. https://doi.org/10.2471/BLT.17.206441
Mishra, P., Pandey, C. M., Singh, U., Gupta, A., Sahu, C., & Keshri, A. (2019). Descriptive statistics and normality tests for statistical data. Annals of Cardiac Anaesthesia, 22(1), 67–72. https://doi.org/10.4103/aca.ACA_157_18
Miyauchi, T., Nishiwaki, H., Mizukami, A., & Yazawa, M. (2023). Hyponatremia and mortality in patients undergoing maintenance hemodialysis: Systematic review and meta-analysis. Seminars in Dialysis, 36(4), 303–315. https://doi.org/10.1111/sdi.13140
National Kidney Foundation. (2024, April 26). Hemodialysis. https://www.kidney.org/kidney-topics/hemodialysis
Neugarten, J., & Golestaneh, L. (2019). Influence of sex on the progression of chronic kidney disease. Mayo Clinic Proceedings, 94(7), 1339–1356. https://doi.org/10.1016/j.mayocp.2018.12.024
Park, Y., & Hwang, W. M. (2025). Management of elderly patients with chronic kidney disease. Yonsei Medical Journal, 66(2), 63–74. https://doi.org/10.3349/ymj.2024.0178
Radhakrishnan, R. C., Kalra, P. A., & Sinha, S. (2019). Effects of individualized dialysate sodium prescription in hemodialysis patients. Kidney International Reports, 5(1), 46–53. https://doi.org/10.1016/j.ekir.2019.10.006
Rhee, C. M., Ravel, V. A., Ayus, J. C., Sim, J. J., Streja, E., Mehrotra, R., Amin, A. N., Nguyen, D. V., Brunelli, S. M., Kovesdy, C. P., & Kalantar-Zadeh, K. (2016). Pre-dialysis serum sodium and mortality in a national incident hemodialysis cohort. Nephrology Dialysis Transplantation, 31(6), 992–1001. https://doi.org/10.1093/ndt/gfv341
Ronco, C., & Clark, W. R. (2018). Haemodialysis membranes. Nature Reviews Nephrology, 14(6), 394–410. https://doi.org/10.1038/s41581-018-0002-x
Rosner, M., Reis, T., Husain-Syed, F., Vanholder, R., Hutchison, C., Stenvinkel, P., Blankestijn, P., Cozzolino, M., Juillard, L., Kashani, K., Kaushik, M., Kawanishi, H., Massy, Z., Sirich, T., Zuo, L., & Ronco, C. (2021). Classification of uremic toxins and their role in kidney failure. Clinical Journal of the American Society of Nephrology, 16(12), 1918–1928. https://doi.org/10.2215/CJN.02660221
Sterns, R. H. (2015). Disorders of plasma sodium—Causes, consequences, and correction. The New England Journal of Medicine, 372(1), 55–65. https://doi.org/10.1056/NEJMra1404489
Sun, L., Hou, Y., Xiao, Q., & Du, Y. (2017). Association of serum sodium and risk of all-cause mortality in patients with chronic kidney disease: A meta-analysis and systematic review. Scientific Reports, 7, 15949. https://doi.org/10.1038/s41598-017-16236-2
Zhang, Z., Zheng, L., Pan, Y., & Wang, M. (2022). The impact of chronic pre-dialysis hyponatremia on clinical outcomes in maintenance hemodialysis patients. International Urology and Nephrology, 54(12), 3221–3232. https://doi.org/10.1007/s11255-022-03241-1
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